In this presentation from AAO 2015, Dr. Anthony J. Aldave discusses the increasing incidence of post-DSEK interface infections and shares recommendations for their diagnosis and treatment. Approximately 2/3rds of the infections are caused by fungi (mostly Candida), presenting with slowly increasing interface opacities which might be confirmed through confocal microscopy. Obtaining a culture often is impossible, so it is very useful to have cultures from the donor rim. Oral and systemic therapies do not resolve the infection; typically a penetrating keratoplasty to remove both host and donor graft is necessary. However, intralamellar antifungal injections have shown effectivity.