This video address the symptoms, diagnosis and treatment of Stevens-Johnson syndrome, a potentially blinding vessicobullous disorder of the skin with ocular involvement in 50% to 80% of cases. Patients usually present with fever, malaise, cough, rhinorrhea, and anorexia, followed by inflammation and ulcerations of the ocular, oral, and genital mucosa. Ocular symptoms are highly variable and can range from self-limited conjunctival hyperemia to near-total sloughing of the entire ocular surface. Early intervention is crucial in these cases, and early placement of amniotic membrane has become the mainstay of treatment and has improved outcomes.