In this presentation from AAO 2015, Dr. James Chodosh discusses a case of varicella zoster keratitis in a 56-year-old woman who had previously presented with herpes zoster ophthalmicus. She was treated successfully with a course of systemic valacyclovir combined with other systemic and topical medications, and she used low-frequency topical rimexolone 1% to maintain her cornea for several years. After 2 years with no follow-up, the patient re-presented with mild foreign-body sensation and 3 areas of neovascularization. Dr. Chodosh notes that a large-scale, prospective zoster eye disease study is needed to address incidences of differing forms of the disease (epithelial, endothelial, and stromal with or without ulceration), optimal treatment plans, and the role of vaccination in patients with past eye complications.