In this presentation from AAO 2015, Todd P. Margolis, MD, PhD, discusses the management of chronic and recurrent varicella zoster virus (VZV), focusing on antiviral prophylaxis, acute disease treatment, and immune response treatment. Dr. Margolis recommends use of systemic antiviral regimens over topical antivirals or high corticosteroid use to prevent recurrence or ocular complications such as neurotrophic keratopathy or postherpetic neuralgia. Acyclovir, Valacylcovir and Famiclovir are equally effective, but many physicians get the dosing wrong. Chronic and recurrent ocular VZV may cause uveitis, iritis or keratitis due to viral DNA and antigens persisting for many years in the cornea.