DEC 08, 2008
Current therapeutic modalities have been helpful in treating many patients with ocular surface disease and dysfunctional tear syndrome. But there remains a subset of patients who continue to have signs and symptoms in spite of aggressive lubricant and anti-inflammatory therapy. Accumulating evidence suggests that meibomian gland dysfunction and ocular surface irritation may be related to systemic androgen deficiency or insensitivity, particularly in women. This article presents evidence supporting this hypothesis and an overview of androgen production, diagnosis and treatment of deficiency states.