Choroidal neovascularization (CNV). A, CNV located between the inner (arrow) and outer (arrowhead) layers of Bruch membrane (sub-RPE, type 1 CNV). Note loss of the overlying photoreceptor inner and outer segments, RPE hyperplasia, and the PAS-positive basal laminar deposit (arrow). B, Surgically excised CNV (subretinal, type 2 CNV) composed of fibrovascular tissue (asterisk) lined externally by RPE (arrow) with adherent photoreceptor outer segments (arrowhead) (H&E stain).