Geographic atrophy of the RPE. A, Fundus photograph shows focal geographic atrophy of the RPE (arrowhead) and drusen in nonexudative age-related macular degeneration. B, Histologically, there is loss of the photoreceptor cell layer, RPE, and choriocapillaris (left of arrow) with an abrupt transition zone (arrow) to a more normal-appearing retina and RPE (right of arrow). Note the multicellular, thick ganglion cell layer identifying the macular region (H&E stain).