In this discussion from ASCRS 2015, Drs. Cynthia Matossian and John Hovanesian offer tips for using a new FDA-approved ocular sealant, ReSure. ReSure Sealant is a synthetic polyethylene glycol-based hydrogel. It comes as two liquid solutions that the surgeon mixes together and applies to the incision using a foam-tipped applicator. The material then gels on the surface of the eye in less than 20 seconds. Once the ReSure material gels, it remains localized over the incision to seal the wound and form a lubricious surface barrier. The material is designed to stay on the incision in the immediate postoperative period when wounds are most vulnerable, after which it sloughs off in the patient’s tears