Sickle-C Disease: Salmon Patch
The round orange patches are hemorrhagic infarctions on the peripheral retinal surface. They are caused by sickling occlusion of arterioles, occurring most commonly in SC and S-thal, uncommonly in SS, and very rarely in AS.
The patient is usually unaware of these hemorrhages because they are far away from the central retina. But they may be the first stage of a process that leads to formation of peripheral retinal neovascularization, bleeding, and retinal detachment. That combination ends in blindness.
Laser photocoagulation can interrupt this cascade, especially if applied at an early stage. This is why all SC and S-thal patients require periodic ophthalmologic examination.