-: Hello, I'm Eric Crowell
here with the Academy's ONE Network.
Speaking with Dr. Wungrak Choi this afternoon,
and we're going to discuss his recent work
in the predicting the safety zone
for steroid-induced ocular hypertension
that's induced by the dexamethasone implant.
Dr. Choi, would you tell us a little bit
about what your findings were for this study?
-: Of course.
Thank you, Eric.
Hello, colleagues from AAO.
My name is Wungrak Choi.
I'm an assistant professor
in glaucoma division, Severance Hospital,
Yonsei University College of Medicine in Korea.
Actually our study,
we try to predict the possibility
of steroid-induced ocular hypertension
after interpreters third implantation,
and to identify the proper safety zone for such injections.
So we actually included 908 eyes
that underwent steroid implant injection,
and the IOP was measured before the injection
and after one week, and one month,
2, 3, 6, and 12 months after that.
And then we done
the univariable logistic regression analysis
to assess the significant associations
between the steroid-induced ocular hypertension
and some covariates.
So we had found some significant variables
and then we analyzed them with the multivariable model.
And then we developed two predicted nomographs
for steroid-induced ocular hypertension.
And after that we offered some cutoff values
for the safety zone
after the interpreters steroid injection.
Eric: That sounds really great.
That's great.
I think that'll be really, really helpful, clinically.
Could you tell me what a couple of the variables
that are maybe a little bit more concerning
that might indicate
that there could be an ocular hypertension
after the Ozurdex injection or the dexamethasone implant?
Wungrak: Yes, of course.
The most strongest point for there
was there were several significant values.
There was age, sex, axial lengths,
and what type of glaucoma the patient had,
previous UVS history, and diabetes.
There were those kinds of stuff.
And the most strongest part was the agent axial lengths.
So when you were young
and if you have high myopia,
they have a lot of possibility
to have steroid-induced ocular hypertension.
Eric: That's great.
How do you think this
is going to change your practice, specifically?
-: Yeah, this study is important
because this was the first time to actually try
to predict the possibility
of steroid-induced hypertension in glaucoma.
And so both clinicians and patients
may benefit from the study.
For clinicians,
they may avoid the unwanted ocular hypertension
and even though the patient
do develops ocular hypertension,
clinicians may be prepared for it.
And for patients, they may be warned
for the risk of steroid treatment
and may have a chance to choose a safer option.
So that's the importance of our study, I think.
Eric: That's great, thank you so much.
I think this is really important work and I'm really excited
that you guys have a poster to present here at Academy.
For the ONE Network, I'm Eric Crowell with Dr. Choi,
and we've been talking about a safety zone
and kind of predictive factors
for what might cause ocular hypertension
after the dexamethasone implant.