Clear Lens Extraction in Primary Angle Closure with or without Glaucoma

The EAGLE Study is a landmark study in the management of primary angle closure (PAC) with an IOP of 30 mm Hg or greater, or PAC glaucoma, in which patients were randomized to primary CLE vs. standard therapy including medical management and laser iridotomy. At 3 years, CLE showed greater efficacy and was more cost-effective than laser peripheral iridotomy, and should be considered as an option for first-line treatment.