By Gregory Moloney, MD; Simon P. Holland, MD; Martin McCarthy
    AAO 2015
    Cornea/External Disease

    In this video, the authors describe spontaneous corneal clearing following descemetorhexis without transplantation in 3 eyes of 2 patients, the first following iatrogenic trauma and the second and third as an intentional surgical intervention for Fuchs endothelial dystrophy. Full corneal clarity was restored with best spectacle-corrected visual acuity of 20/20 at 12 months in all cases. Clinical and confocal microscopic findings suggest there is a mitotic and migratory healing capacity of the human corneal endothelium that can be exploited in select cases. The authors also discuss hypotheses for future research.