Cornea Subspecialty Day 2016
    Cornea/External Disease, Ocular Surface Disease

    Dr. Jennifer Rose-Nussbaumer discusses new research into treatments for fungal ulcers, which have a worse prognosis than bacterial keratitis. The NEI-funded Mycotic Ulcer Treatment Trial (MUTT) compared treatment options and found that natamycin remains superior to voriconazole in terms of visual acuity, infiltrate scar size, and corneal perforation rate. However, natamycin does not penetrate deeply into the cornea, so another trial, MUTT II, was initiated to investigate oral voriconazole for deep ulcers. It found that patients with Fusarium ulcers randomized to oral voriconazole were less than half as likely to experience a perforated cornea or require a penetrating keratoplasty (HR 0.43) compared to those on placebo.