A new disposable, automated capsulotomy device (Zepto) using nanopulse technology was tested in rabbit and human cadaver eyes. Precise, perfectly circular capsulotomies were reproducibly completed in 20 seconds through a clear corneal incision. Scanning electron microscopy showed a smooth capsule edge that resembled a manual continuous curvilinear capsulorhexis (CCC). Using quantitative stretch testing in paired human cadaver eyes, the nanopulse capsulotomy was consistently and statistically stronger than the femtosecond laser or manual CCC. Thermocoupling measurements showed no significant intraocular temperature rise, and Miyake-Apple imaging showed no zonular stress. This technology might prove able to automate and shorten the procedural time for the capsulotomy step at an affordable cost, all without disrupting patient flow in the OR.