In this presentation from the 2012 Annual Meeting, Dr. William Dupps discusses how crosslinking (CXL) has implications across the 3 functional areas of the cornea (mechanical barrier, immunological barrier, and geometrical scaffold for the most influential refractive surface of the eye) and how integration will involve further convergence of corneal and refractive surgery practices. Topics include access issues, the daunting number of combination therapies, simulation, patient-specific modeling, risk assessment, keratoconus progression, cones, and measuring 3D elastic properties.