The inverted internal limiting membrane (ILM) flap technique, first reported by Michalewska et al. in 2010, is considered an effective surgical technique for treating large, idiopathic, full-thickness macular holes (FTMH) and myopic macular holes (MH). This innovative technique increased the rate of complete macular hole closure to 98% for large, idiopathic MHs (diameter exceeding 400 µm) and to about 100% for high-myopic MHs.