Dr. James Chodash discusses the management of acute Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). This rare disease is typically diagnosed by the acute onset of flat atypical targets or purpuric macules predominantly on the trunk with involvement of at least 2 mucosal sites. SJS and TEN are defined as:

• SJS: epidermal detachment < 10% of body surface area
• SJS-TEN overlap: 10%–30% detachment of body surface area
• TEN: 30% detachment of body surface area

Ocular complications from SJS/TEN can cause blindness, so early treatment is critical. Dr. Chodash recommends full examination with fluorescein to detect epithelial defects and pseudomembranes, the use of topical corticosteroids, and considering amniotic membrane transplantation as early as possible.