Injection of an air bubble with nearly complete fill of the anterior chamber is an essential step for performing successful Descemet stripping automated endothelial keratoplasty (DSAEK). Trapped air behind the iris with progressive swallowing of the anterior chamber is one of the main reasons for failure to achieve a complete fill. Early identification of this problem and proper management can reverse it. In this video, the authors demonstrate proper management of an air bubble in the anterior chamber. The technique involves withdrawing the air from behind the iris, reinjecting the air bubble, and suturing all incisions.