In this presentation from the AAO 2021 course "New Approaches to the Prevention and Treatment of Myopia: Update 2021," Dr. Andrzej Grzybowski discusses clinical trial outcomes supporting the role of various treatments for preventing myopia or slowing its progression. Dr. Grzybowski reviews the use of atropine, optical options such as spectacles and contact lenses, orthokeratology, and outdoor time, as well as the known side effects of various treatments and combined approaches.