In this presentation from the 2012 Annual Meeting, Dr. Stephen Pflugfelder begins with 5 reasons to use the new tests for dry eye: improve diagnostic capability, guide therapeutic decision making, monitor therapeutic efficacy, identify patients with tear dysfunction, and add revenue. He then reviews new tests including a chip tear osmometer, tear MMP-9 immunoassay, tear imaging, noninvasive tear break-up test (TBUT), tear stability analysis system, Oculus keratograph, tear interferometry, tear meniscus imaging, conjunctival cytology, and periodic acid-schiff (PAS) staining.