By Surbhi Joshi, MD; Santosh G. Honavar, MD; Milind N. Naik, MBBS; Geeta K. Vemuganti, MD; Mohammad Ali; Gangadhar Jalli; Shobha Mocherla
    Ocular Pathology/Oncology

    Sebaceous gland carcinoma is the most common eyelid malignancy in Asia and the Middle East. It masquerades a wide variety of clinical presentations, mimicking several inflammatory and benign conditions of the eyelid and adnexa. The sites of involvement include the eyelid, conjunctiva and caruncle. Clinical variants include a nodule, noduloulcerative lesion, or diffuse infiltrative tumor. Excision with margin control along with a map biopsy to rule out pagetoid invasion is the preferred treatment. Neoadjuvant chemotherapy, orbital exenteration and adjuvant radiotherapy are considered in tumors with orbital extension or regional lymph node metastasis. The rate of local recurrence rate with the protocol based approach of management is less than 5%.