This video reports clinical and histopathological findings of uveal effusion syndrome in nanophthalmos and its surgical treatment. Vitrectomy combined with 4 posterior partial-thickness scleral resections is described. The authors conclude that the progressive accumulation of amyloid may account for an increase in scleral thickness and rigidity, reducing the uveoscleral outflow and causing glaucoma and chorioretinal detachments. Scleral resection is an effective and recommended treatment.