This is part of the series on Spotlight on Pediatric Ophthalmology: Front Line and First Steps — Management of Strabismus. Panelists include pediatric ophthalmologists, strabismus surgeons, and neuro-ophthalmologists. Following a case-based format, speakers highlight clinical pearls on accommodative esotropia, intermittent exotropia, isolated cranial neuropathies, diplopia in an elderly patient, thyroid eye disease, and sensory strabismus. Viewers will learn about the use of prisms for diplopia management, when to image, and other pearls in systemic workup for diplopia as well as strategies for examining and managing uncooperative children.