Dr. Graham Quinn discusses randomized surgical treatment trials that included defined cohorts with zone I retinopathy of prematurity (ROP), such as CRYO-ROP, ETROP and BEAT-ROP. Treatments used included cryotherapy, laser therapy and intravitreal injection. He reviews enrollment criteria and results, and also covers cohort and case studies of laser therapy for zone I ROP and other papers relevant to treatment with bevacizumab.