The authors demonstrate their rescue strategy for a retinal break that complicated a 3-port 23-gauge vitrectomy for stage 4a-4b ROP surgery. The size and location of the iatrogenic break are most critical to success. If the break is small and in a silent area, it can be managed with as little as a gas tamponade. If it is large and in an area of prominent fibrovascular proliferation and traction, reattachment is unlikely.