Fundus autofluorescence (FAF) imaging is a useful tool for diagnosing a variety of macular and retinal degenerations, as well as disorders such as parafoveal telangiectasis in which depletion of luteal pigment can result in abnormal foveal autofluorescence. With the introduction of widefield imaging devices—in particular the Optos 200Tx—the use of FAF has led to discoveries of peripheral autofluorescence patterns characteristic of certain diseases. Dr. Srinivas Sadda describes some of the most common patterns of abnormal autofluorescence that will be studied more extensively in the OPERA arm of the AREDS2 trial.