Straight From the Cutter's Mouth
    Macular Disease, Retina/Vitreous

    This special edition episode recorded from Vancouver Canada at the 2019 ARVO meeting highlights the DRCR.net Protocol V clinical trial that examined anti-VEGF versus laser versus observation for patients with diabetic macular edema and very good vision. This 2-part episode starts with a discussion on the study design and results with the senior investigators Dr. Jennifer Sun and Dr. Carl Baker. In the second half, Drs. Emily Chew and George Williams join the program to discuss real-world implications of these results. The full published manuscript of Protocol V was published in JAMA.

    Relevant Financial Disclosures: Dr. Baker reports receipt of grants for clinical research from Regeneron, Genentech, Allergan and Novartis. Dr. Sun reports receipt of grants from Roche Genentech, Juvenile Diabetes Research Foundation, and Kalvista; personal fees from Current Diabetes ReportsJAMA Ophthalmology and Merck; and nonfinancial support from Optovue (equipment loaned for research), Roche Genentech (food/beverage), and KalVista (travel support). Drs. Sridhar, Williams, and Chew have no relevant financial disclosures.

    CME Information

    Release: May 3, 2019; expires May 3, 2022

    Reviewers: Purnima Patel, MD; Shriji Patel, MD; Carl Danzig, MD

    Disclosures: The physician reviewers and Academy staff report no relevant financial disclosures.

    Learning Objective: Upon completion of this episode, the listener should be able to describe evolving standards of care for the management of vitreoretinal disorders or the outcomes from recent research and how these impact patient care decisions.

    Audience: This activity is intended for retina subspecialists and comprehensive ophthalmologists.

    Accreditation: The American Academy of Ophthalmology is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
    The American Academy of Ophthalmology designates this enduring material for a maximum of 0.5 AMA PRA Category 1 Credits.
    TM Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Hardware/Software Requirements: This learning activity requires a current web browser and speaker or headset capable of playing streaming audio.