In general, soft-tissue tumors are diagnosed both by recognition of the histologic patterns (ie, round cell, spindle cell, myxoid, epithelioid, pericytomatous, and pleomorphic) and by IHC. The characteristic pathologic features of soft-tissue tumors often overlap and are described on websites such as PathologyOutlines.com (www.pathologyoutlines.com/eye.html). Initially, a panel of IHC stains is used to narrow the differential diagnosis, and those results may direct further studies; however, it may be challenging to classify these tumors even with the assistance of an experienced soft-tissue pathologist.
Excerpted from BCSC 2020-2021 series: Section 4 - Ophthalmic Pathology and Intraocular Tumors. For more information and to purchase the entire series, please visit https://www.aao.org/bcsc.