Corectopia refers to displacement of the pupil. Normally, the pupil is situated about 0.5 mm inferonasally from the center of the iris. Minor deviations up to 1.0 mm are usually cosmetically insignificant and should probably not be considered abnormal. Sector iris hypoplasia or other colobomatous lesions can lead to corectopia, and isolated noncolobomatous autosomal dominant corectopia has also been reported. More commonly, however, corectopia is associated with lens subluxation, and this combination is called ectopia lentis et pupillae. The condition is almost always bilateral, with the pupils and lenses displaced in opposite directions (see also Chapter 21).
The pupils may be oval or slit-shaped, and they often dilate poorly. Iris transillumination may occur, and microspherophakia has been reported.
Progressive corectopia can be associated with the Axenfeld-Rieger spectrum as well as iridocorneal endothelial (ICE) syndrome. Visual acuity may be good, even with eccentric pupils.