The hyaloid artery connects with the tunica vasculosa lentis just inferior and nasal to the center of the lens in utero. With regression of these vascular structures, a nodular mass of tissue may remain on the posterior lens capsule and appear as a focal posterior lens opacity at this site. This nodule is referred to as Mittendorf dot (see Figure 4-6 in BCSC Section 11, Lens and Cataract).
Excerpted from BCSC 2020-2021 series: Section 4 - Ophthalmic Pathology and Intraocular Tumors. For more information and to purchase the entire series, please visit https://www.aao.org/bcsc.