Treatment of B burgdorferi infection depends on the stage and severity of the infection. Early Lyme disease is typically treated with oral doxycycline, amoxicillin, cefuroxime, or erythromycin. Mild disseminated disease is treated with oral doxycycline or amoxicillin. Serious disease (with cardiac or neurologic manifestations) is typically treated with ceftriaxone or high-dose penicillin G for up to 6 weeks. Infections that do not respond to the initial regimen may require alternate or combination therapy.
Klempner MS, Baker PJ, Shapiro ED, et al. Treatment trials for post-Lyme disease symptoms revisited. Am J Med. 2013;126(8):665–669.
Schwartz AM, Hinckley AF, Mead PS, Hook SA, Kugeler KJ. Surveillance for Lyme disease—United States 2008–2015. MMWR Surveill Summ. 2017;6622:1–12.
Excerpted from BCSC 2020-2021 series: Section 1 - Update on General Medicine. For more information and to purchase the entire series, please visit https://www.aao.org/bcsc.