2020–2021 BCSC Basic and Clinical Science Course™
6 Pediatric Ophthalmology and Strabismus
Part II: Pediatric Ophthalmology
Chapter 28: Ocular Manifestations of Systemic Disease
Intrauterine or Perinatal Infection
Zika virus is a flavivirus transmitted by the Aedes aegypti mosquito. It has recently been associated with congenital microcephaly and chorioretinal lesions. In a series of 29 infants in Brazil with presumed intrauterine Zika virus infection, ocular abnormalities were present in 10 infants (35%) and were bilateral in 7 infants. The characteristic lesions included posterior pole pigmentary clumping and areas of circumscribed chorioretinal atrophy. In addition, 1 baby showed iris colobomas and lens subluxation. Cerebral visual impairment is common.
de Paula Freitas B, de Oliveira Dias JR, Prazeres J, et al. Ocular findings in infants with microcephaly associated with presumed Zika virus congenital infection in Salvador, Brazil. JAMA Ophthalmol. 2016;134(5):529–535.
Excerpted from BCSC 2020-2021 series: Section 10 - Glaucoma. For more information and to purchase the entire series, please visit https://www.aao.org/bcsc.