The great majority of patients with SSc test positive for ANA. Other useful serological tests include anti-DNA topoisomerase I and anti-RNA polymerase III, which are highly specific for the disease. Anticentromere antibody is often present in the limited subtype of SSc. These specific serologies help classify the disease and various syndromes that overlap with SSc.
Excerpted from BCSC 2020-2021 series: Section 1 - Update on General Medicine. For more information and to purchase the entire series, please visit https://www.aao.org/bcsc.