Amyloid deposition in the orbit occurs in primary systemic amyloidosis and is usually benign. When amyloid deposition involves the extraocular muscles and nerves, it can cause ophthalmoplegia and ptosis. See Chapters 5, 6, 10, and 13 in this volume for more information on amyloid.
Excerpted from BCSC 2020-2021 series: Section 4 - Ophthalmic Pathology and Intraocular Tumors. For more information and to purchase the entire series, please visit https://www.aao.org/bcsc.