Special procedures such as immunohistochemistry and flow cytometry, as well as molecular genetic and cytogenetic techniques, have led to improvements in the diagnosis of eye diseases.
The ophthalmic surgeon is responsible for submitting tissue in a manner that allows special studies to be performed when needed. Appropriate submission requires preoperative consultation with the pathologist.
Frozen section pathology should be used when the pathologic results would alter the surgical procedure, as with evaluation of surgical margins when a malignancy is excised.
Excerpted from BCSC 2020-2021 series: Section 4 - Ophthalmic Pathology and Intraocular Tumors. For more information and to purchase the entire series, please visit https://www.aao.org/bcsc.