2020–2021 BCSC Basic and Clinical Science Course™
9 Uveitis and Ocular Inflammation
Chapter 4: Special Topics in Ocular Immunology
Animal Models of Human Uveitis
Interphotoreceptor Retinoid-Binding Protein–Specific T-Cell Receptor Transgenic Mice
Immunization of mice with a peptide sequence from IRBP induces autoimmune uveitis in mice. Mice bred to be transgenic for an IRBP-specific T-cell receptor develop a spontaneous uveitis that begins around 4 weeks of age and progresses to an incidence of 100% by age 12 weeks. These mice provide a model of spontaneous uveitis that negates the need for peripheral immunization and produces a chronic course, in contrast to the more acute disease of classic EAU.
Chen J, Qian H, Horai R, Chan CC, Caspi RR. Mouse models of experimental autoimmune uveitis: comparative analysis of adjuvant-induced vs spontaneous models of uveitis. Curr Mol Med. 2015;15(6):550–557.
Forrester JV, Klaska IP, Yu T, Kuffova L. Uveitis in mouse and man. Int Rev Immunol. 2013;32(1)76–96.
Excerpted from BCSC 2020-2021 series: Section 9 - Uveitis and Ocular Inflammation. For more information and to purchase the entire series, please visit https://www.aao.org/bcsc.