The juxtacanalicular meshwork invests the entire extent of the Schlemm canal and forms its inner wall. On its trabecular aspect, between the outermost layers of the corneoscleral meshwork and the endothelial lining of the Schlemm canal, lies the endothelial meshwork, a multilayered collection of cells forming a loose network. Between these cells are spaces up to 10 μm wide through which aqueous humor can percolate to reach the endothelial lining of the Schlemm canal (Fig 2-15). This region of the drainage system contributes the most to outflow resistance, partly because the pathway is narrow and tortuous and partly because of the resistance offered by extracellular proteoglycans and glycoproteins.
Excerpted from BCSC 2020-2021 series: Section 2 - Fundamentals and Principles of Ophthalmology. For more information and to purchase the entire series, please visit https://www.aao.org/bcsc.