Bilateral Diffuse Uveal Melanocytic Proliferation
Bilateral diffuse uveal melanocytic tumors have been associated with systemic malignancy. Such tumors can be accompanied by rapid vision loss, cataracts, multiple pigmented and nonpigmented placoid iris and choroidal nodules, and serous retinal detachments. This condition can mimic VKH syndrome. Histologic investigation shows diffuse infiltration of the uveal tract by benign nevoid or spindle-shaped cells. Necrosis within the tumors may be present, and scleral involvement is common. The cause of this entity is unknown. Treatment should be directed at finding and treating the underlying primary lesion.
Gangaputra S, Kodati S, Kim M, Aranow M, Sen HN. Multimodal imaging in masquerade syndromes. Ocul Immunol Inflamm. 2017;25(2):160–168.
Excerpted from BCSC 2020-2021 series: Section 9 - Uveitis and Ocular Inflammation. For more information and to purchase the entire series, please visit https://www.aao.org/bcsc.