Corneal inflammation can also be a result of many noninfectious processes. For example, autoimmune diseases, especially rheumatoid arthritis and graft-vs-host disease, may be associated with sterile corneal ulceration and interstitial keratitis. Topical medi cation toxicity (eg, as occurs with overuse of topical anesthetics, nonsteroidal anti-inflammatory drugs [NSAIDs], or antiviral drugs) may also result in corneal melting. Histology varies depending on the etiology, but the unifying feature is absence of organisms. See also BCSC Section 8, External Disease and Cornea.
Excerpted from BCSC 2020-2021 series: Section 4 - Ophthalmic Pathology and Intraocular Tumors. For more information and to purchase the entire series, please visit https://www.aao.org/bcsc.