Macular Telangiectasia Type 1
Macular telangiectasia type 1 (MacTel 1), also termed aneurysmal telangiectasia, typically occurs unilaterally, predominantly in young males, and with characteristic aneurysmal dilatations of the temporal macular vasculature with surrounding CME and yellowish exudates. MacTel 1 is considered a a macular variant of Coats disease. Peripheral vascular changes may also occur. Anti-VEGF therapy is generally ineffective. However, aflibercept, which blocks placental growth factor in addition to VEGF, elicits a treatment response in eyes with MacTel 1, implicating placental growth factor in the pathogenesis of the disease.
Excerpted from BCSC 2020-2021 series: Section 10 - Glaucoma. For more information and to purchase the entire series, please visit https://www.aao.org/bcsc.