2020–2021 BCSC Basic and Clinical Science Course™
9 Uveitis and Ocular Inflammation
Chapter 4: Special Topics in Ocular Immunology
Animal Models of Human Uveitis
Endotoxin-induced (also termed experimental immune) uveitis (EIU) is a transient uveitis model induced by footpad, intraperitoneal, or intravitreal injection of lipopolysaccharide in mice and rats (see Chapter 1). Sixteen to 48 hours after administration, a transient anterior uveitis develops. This model has been especially useful for studies of the dynamics of leukocyte function in the anterior chamber. It is not clear how or even if this model correlates with human disease.
Excerpted from BCSC 2020-2021 series: Section 9 - Uveitis and Ocular Inflammation. For more information and to purchase the entire series, please visit https://www.aao.org/bcsc.