Lymphocytic Choriomeningitis Virus
Lymphocytic choriomeningitis virus (LCMV) is an under-recognized fetal teratogen that should probably be listed among the “other agents” in the TORCH group of congenital infections. The microbe is a single-stranded RNA virus of the Arenaviridae family.
Systemic findings include macrocephaly, hydrocephalus, and intracranial calcifications. Neurologic abnormalities, seizures, and mild cognitive impairment may occur. Ocular findings include macular and peripheral chorioretinal scars, similar in morphology and distribution to congenital toxoplasmosis. Serologic testing of the mother and the infant helps differentiate. Other findings include optic atrophy, strabismus, and nystagmus.
Mets MB, Barton LL, Khan AS, Ksiazek TG. Lymphocytic choriomeningitis virus: an underdiagnosed cause of congenital chorioretinitis. Am J Ophthalmol. 2000;130(2):209–215.
Excerpted from BCSC 2020-2021 series: Section 9 - Uveitis and Ocular Inflammation. For more information and to purchase the entire series, please visit https://www.aao.org/bcsc.