Retinal Pigment Epithelial Hyperplasia
When stimulated by chronic low-grade traction, retinal pigment epithelial cells proliferate. Diffuse retinal pigment epithelial hyperplasia may be observed straddling the ora serrata, in latitudes that correspond roughly to the insertion of the vitreous base. They may also occur focally on the pars plana and peripheral retina, especially in areas of focal traction such as vitreoretinal tufts and lattice degeneration. Areas of previous inflammation and trauma may also be sites of retinal pigment epithelial hyperplasia.
Figure 16-10 Gross appearance of paving-stone degeneration.
(Used with permission from Green WR. Pathology of the retina. In: Frayer WC, ed. Lancaster Course in Ophthalmic Histopathology, unit 9, Philadelphia: FA Davis; 1988:181.)
Excerpted from BCSC 2020-2021 series: Section 10 - Glaucoma. For more information and to purchase the entire series, please visit https://www.aao.org/bcsc.