Primary hyperparathyroidism is most commonly associated with benign proliferation of chief cells within a single parathyroid gland and, in rare cases, with MEN. Secondary hyperparathyroidism can be caused by renal disease in which excessive amounts of calcium are lost and the glands release a compensatory amount of parathyroid hormone. Parathyroid hyperplasia can occur in the presence of hypercalcemia and hypophosphatemia associated with milk-alkali syndrome, sarcoidosis, and excessive intake of vitamin D. Calcium deposition can occur despite normal parathyroid function and normal levels of systemic serum calcium. See Chapter 6 for further discussion.
Table 8-7 Conditions Associated With Prominent Corneal Nerves
Figure 8-16 Prominent corneal nerves.
(Courtesy of Robert W. Weisenthal, MD.)
If symptomatic with decreased vision or discomfort, the calcium can be removed with EDTA.
Darvish-Zargar M, Bartow RM. Endocrine disease and the cornea. In: Mannis MJ, Holland EJ, eds. Cornea. Vol 1. 4th ed. Philadelphia: Elsevier; 2017:696–704.
Excerpted from BCSC 2020-2021 series: Section 10 - Glaucoma. For more information and to purchase the entire series, please visit https://www.aao.org/bcsc.