Examples of animal models of human uveitis include experimental autoimmune uveoretinitis, endotoxin-induced uveitis, equine recurrent uveitis, autoimmune regulator–deficient mice, and interphotoreceptor retinoid-binding protein (IRBP)–specific T-cell receptor transgenic mice.
All animals with white blood cells express a family of cell-surface glycoproteins called major histocompatibility complex (MHC) proteins. In humans, the MHC proteins are called human leukocyte antigen (HLA) molecules.
The presence of many different HLA alleles within a population should ensure that the collective adaptive immune system will be able to respond to a wide range of potential pathogens. However, some individuals might be at increased risk for immunologic diseases.
Excerpted from BCSC 2020-2021 series: Section 9 - Uveitis and Ocular Inflammation. For more information and to purchase the entire series, please visit https://www.aao.org/bcsc.