Ipsilateral periorbital pain that increases with eye movement occurs commonly in optic neuritis. Associated neurologic symptoms may suggest demyelinating disease. Nonspecific pain, facial numbness, or diplopia may indicate an orbital or cavernous sinus lesion. Headache, jaw claudication, and systemic symptoms suggest giant cell arteritis (GCA).
Excerpted from BCSC 2020-2021 series: Section 5 - Neuro-Ophthalmology. For more information and to purchase the entire series, please visit https://www.aao.org/bcsc.