2020–2021 BCSC Basic and Clinical Science Course™
4 Ophthalmic Pathology and Intraocular Tumors
Part I: Ophthalmic Pathology
Chapter 11: Retina and Retinal Pigment Epithelium
The clinical features of various retinal degenerations are discussed in BCSC Section 12, Retina and Vitreous.
Typical and Reticular Peripheral Cystoid Degeneration and Retinoschisis
In typical peripheral cystoid degeneration (TPCD), which is a universal finding in the eyes of individuals older than 20 years, cystoid spaces develop in the OPL of the retina. In reticular peripheral cystoid degeneration (RPCD), which is less common than TPCD, cystoid spaces develop in the NFL, posterior to areas of TPCD (Fig 11-11). Coalescence of the cystoid spaces of TPCD forms typical degenerative retinoschisis, usually in the inferotemporal region. In reticular degenerative retinoschisis, the retinal layers split in the NFL.
Figure 11-11 Typical peripheral cystoid degeneration (TPCD) consisting of cystoid spaces in the outer plexiform layer (asterisk). The anterior eye is toward the left side of the photograph. Reticular peripheral cystoid degeneration (RPCD) is posterior to the TPCD (arrow) in the nerve fiber layer. Coalescence of these cystoid spaces results in retinoschisis.
Excerpted from BCSC 2020-2021 series: Section 4 - Ophthalmic Pathology and Intraocular Tumors. For more information and to purchase the entire series, please visit https://www.aao.org/bcsc.