Brown syndrome is a restrictive ocular motor disorder that produces limited upgaze when the affected eye is in the adducted position. It is usually congenital but can be acquired. Acquired Brown syndrome is typically found in patients with rheumatoid arthritis, idiopathic orbital inflammatory disease, or trauma, including iatrogenic trauma, but in rare cases, it may be a manifestation of a focal neoplastic metastasis to the superior oblique muscle (see BCSC Section 6, Pediatric Ophthalmology and Strabismus).
Excerpted from BCSC 2020-2021 series: Section 5 - Neuro-Ophthalmology. For more information and to purchase the entire series, please visit https://www.aao.org/bcsc.