Intravenous antibiotic therapy with 1.5 MU of penicillin G every 6 hours or oral doxycycline, 100 mg twice daily for 1 week, may be used for mild or moderate cases. It is not known whether systemic antibiotic treatment is protective with respect to long-term complications such as uveitis. However, systemic antibiotic treatment should be considered for ocular disease that occurs even months after onset of the acute systemic disease. In addition, topical, periocular, or systemic corticosteroids, together with mydriatic and cycloplegic drugs, are routinely used to suppress intraocular inflammation. The visual prognosis of leptospiral uveitis is quite favorable despite severe panuveal inflammation.
Excerpted from BCSC 2020-2021 series: Section 9 - Uveitis and Ocular Inflammation. For more information and to purchase the entire series, please visit https://www.aao.org/bcsc.