• By Rahul Khurana, MD
    Central retinal vein occlusion (CRVO) is a sight-threatening condition with an annual incidence of 30,000 eyes in the United States,1 while macular edema (ME) is a frequent cause of vision loss in eyes with CRVO with limited therapeutic options.2 Until recently, there were n…
    Current Insight
    By Kumiko Nakao, MD, PhD; Taiji Sakamoto, MD, PhD
    Optic disc change is frequently associated with Vogt-Koyanagi-Harada disease (VKH) but not studied in great detail. While optic disc change may hamper the correct diagnosis of VKH, the presence of VKH may also hinder the diagnosis of optic disc disease. This article explores…
    Current Insight
    By Dennis P. Han, MD
    The Endophthalmitis Vitrectomy Study (EVS) has strongly influenced the management of acute postoperative endophthalmitis since the release of its findings in 1995.1 The EVS confirmed the visual benefit of pars plana vitrectomy in patients presenting with visual acuity of lig…
    Current Insight
    By Helen K. Li, MD
    Rapidly evolving computer technology is supplementing face-to-face patient examinations and expanding the reach of diabetic retinopathy evaluations. Diabetic retinopathy remains a leading cause of blindness, even though timely treatment has been proven to dramatically reduce…
    Current Insight
    By SriniVas R. Sadda, MD; Alexander C. Walsh, MD
    Following its original description by Huang and workers in 1991, optical coherence tomography (OCT) has steadily evolved into an integral element in the diagnosis and management of patients with posterior segment disease.1-4 OCT presented 2 significant advances over existing…
    Current Insight
    By Richard F. Spaide, MD
    Fundus Paintings and PhotographsEarliest forms of ocular imaging attempted to obtain representations of the ocular fundus as similar as possible to that seen by ophthalmoscopy. Paintings of various ocular diseases were used as plates in older texts, and often were renderings…
    Current Insight
    By William J. Wirostko, MD
    IntroductionFine-needle aspiration (FNA) biopsy of choroidal melanoma is an old diagnostic technique that is currently enjoying renewed interest. It involves inserting a small-gauge needle (25- or 27-gauge, most commonly) into an intraocular tumor via either a transcleral or…
    Current Insight
    By G. Atma Vemulakonda, MD; Christina J. Flaxel, MD
    Endophthalmitis is a potentially serious complication of any intraocular procedure. West et al. revealed that from 1994 to 2001, the incidence of presumed infectious endophthalmitis after cataract surgery rose to 2.15 per 1000 cataract surgeries.1 Although the Endophthalmiti…
    Current Insight
    By Ron A. Adelman, MD, MPH; Adarsh V. Arya, MD
    Increased life expectancy concomitant with phacoemulsification’s enhanced safety and success have galvanized the popularity of cataract surgery. Consequently, pseudophakic retinal detachment (RD) has emerged as a relatively common entity distinct from phakic rhegmatogenous R…
    Current Insight
    By Scott W. Cousins, MD; Karl G. Csaky, MD, PhD
    The practice of medicine has changed dramatically over the last few decades. It is far more complex and requires a wider scope of understanding than ever before. In part from major breakthroughs in our understanding of the pathogenesis of diseases, and partly from new molecu…
    Current Insight
    By Steven T. Bailey, MD; J. Timothy Stout, MD, PhD, MBA
    Familial aggregation studies, segregation analyses, and twin studies have provided strong evidence for a significant genetic role in the etiology of age-related macular degeneration (AMD) (Surv Ophthalmol. 2006;51:313-363). It is unlikely that researchers will pinpoint a sin…
    Current Insight
    By Prithvi Mruthyunjaya, MD
    Even with aggressive systemic treatments, metastatic liver disease remains the most common cause of tumor-related mortality in choroidal malignant melanoma (CMM) with a median survival rate of 2 to 7 months and a 1-year survival rate of less than 10%. However, recent estimat…
    Current Insight
    By Leon A. Bynoe, MD
    The Central Vein Occlusion Study (CVOS) demonstrated that only 6% of eyes with central retinal vein occlusion (CRVO) and a visual acuity of 1 These results highlight the need to find ways to help CRVO patients successfully recover vision. Although small, non-randomized case…
    Current Insight
    By Philip J. Rosenfeld, MD, PhD
    At the recent World Congress of Ophthalmology in Brazil, ophthalmologists from all over the world shared their positive experiences with the off-label use of intravitreal Avastin for the treatment of retinal and choroidal vascular diseases. Few innovations in medicine have b…
    Current Insight
    By Michael S. Ip, MD
    Despite a proliferation of new ophthalmic drugs and technologies in recent years that require evaluation by well-conducted clinical trials, many physicians have encountered difficulty in  recruiting patients for clinical trials. Because few working physicians can spare…
    Current Insight